�UroToday.com - This study by Dr. Pramod Reddy et al. evaluated the use of tolterodine in children with neurogenic detrusor overactivity. The efficacy of the do drugs was evaluated urodynamically and using parent-completed 3-day bladder diaries. The study was done prospectively. They received drug preparation and dosing based on age.
They found that functional bladder capacity increased within one year in the younger patients just not in the elderly patients. The first condensation in detrusor leak stage pressure did not change in any age mathematical group. The identification number of incontinence episodes reduced for all the patients, as did the number of catheterizations utilized in the 24-hour period to keep dry. The hateful volume per catheterization increased in all subjects. Seven of the 30 subjects who were enrolled showed treatment-related adverse events.
The group complete that tolterodine formulations were effective and well tolerated in children with neurogenic detrusor overactivity. This is a helpful first step since the long-acting tolterodine might play a persona for these children at one time the short-acting dose is tolerated.
Ellsworth PI, Borgstein NG, Nijman RJ, Reddy PP
J Urol. 2005 Oct;174(4 Pt 2):1647-51
doi:10.1097/01.ju.0000176622.81796.89
Reported by UroToday.com Medical Editor Pasquale Casale, MD
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